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Article

Effect of carbapenem and VPA coadministration on seizure outcomes: a retrospective single-center study

2026-04-01

Abstract excerpt

<title>Abstract</title> <p> Background The concomitant use of carbapenem antibiotics and valproate is generally avoided because carbapenems markedly reduce serum valproate concentrations, raising concern about increased seizure risk. However, robust clinical evidence linking this pharmacokinetic interaction to worsened seizure control remains scarce. Methods This single‑center, retrospective, self‑controlled s...

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Literature Corpus work
2cce3510-2d8a-5489-ba4b-cea554c71ee1
DOI
10.21203/rs.3.rs-9145557/v1
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Effect of carbapenem and VPA coadministration on seizure outcomes: a retrospective single-center studyDOI 10.21203/rs.3.rs-9145557/v1
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