Article

A repetitive mutation and selection system for bacterial evolution to increase the specific affinity to pancreatic cancer cells

2017-11-10

Abstract excerpt

It is difficult to target and kill cancer cells. One possible approach is to mutate bacteria to enhance their binding to cancer cells. In this study, Gram-negative bacteria Escherichia coli and Gram-positive bacteria Bacillus subtilis were randomly mutated, and then were positively and negatively selected for binding cancer and normal cells. With repetitive mutation and selection both bacteria successfully evolv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cca58d0-7d88-55f5-9ebc-270b291407b0
DOI: 10.1101/217893

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A repetitive mutation and selection system for bacterial evolution to increase the specific affinity to pancreatic cancer cellsDOI 10.1101/217893Read

A repetitive mutation and selection system for bacterial evolution to increase the specific affinity to pancreatic cancer cells.Semantic proximity Read

Bacteriotherapy in Breast CancerSemantic proximity Read

MinD plays an important role in Aeromonas hydrophila adherence to Anguilla japonica mucus.Semantic proximity Read

In pursuit of cancer metastasis therapy by bacteria and its biofilms: History or future.Semantic proximity Read

Identification of the mutual gliding locus as a factor for gut colonization in non-native bee hosts using the ARTP mutagenesis.Semantic proximity Read

Haemophilus influenzae porine ompP2 gene transfer mediated by graphene oxide nanoparticles with effects on transformation process and virulence bacterial capacity.Semantic proximity Read

A modified Janus cassette (Sweet Janus) to improve allelic replacement efficiency by high-stringency negative selection in Streptococcus pneumoniae.Semantic proximity Read

Selection for non-specific adhesion is a driver of FimH evolution increasing <i>Escherichia coli</i> biofilm capacitySemantic proximity Read

Enhancing the soluble expression of an amylase in Escherichia coli by the mutations related to its domain interactions.Semantic proximity Read

Enhanced bacterial mutualism through an evolved biofilm phenotype.Semantic proximity Read

Construction of a Mutant in Prevotella melaninogenica Using the Conjugation Transfer Method with Escherichia coli.Semantic proximity Read

The Pseudomonas aeruginosa type IV pilin receptor binding domain functions as an adhesin for both biotic and abiotic surfaces.Semantic proximity Read