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Article

A repetitive mutation and selection system for bacterial evolution to increase the specific affinity to pancreatic cancer cells.

PloS one - 1 Jan 2018

Osawa Masaki

Abstract excerpt

It is difficult to target and kill cancer cells. One possible approach is to mutate bacteria to enhance their binding to cancer cells. In the present study, Gram-negative Escherichia coli and Gram-positive Bacillus subtilis were randomly mutated, and then were positively and negatively selected for binding cancer vs normal cells. With repetitive mutation and selection both bacteria successfully evolved to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29851969
DOI: 10.1371/journal.pone.0198157
PMCID: PMC5979011

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