Article

Identifying potential therapeutic targets for T-cell acute lymphoblastic leukemia using malignant networks and topological analysis

2025-10-09

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and heterogeneous disease requiring new therapeutic targets. We identified overexpressed genes in T-ALL cell lines, built subnetworks using the IntAct interactome, and evaluated the topological role of each gene. An attack strategy, removing one gene at a time, was applied with eleven network measures and persistent homology. A positive control group of...

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Literature Corpus work: 2c86c6b7-b881-5e2f-bf0a-69474809414d
DOI: 10.1101/2025.10.08.681235

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