Article

The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration

2018-07-30

Abstract excerpt

<h4>Summary</h4> Loss of function of the tumor suppressor p53 is generally thought to increase cell motility and invasiveness. Using 2-D confluent and 3-D spheroidal cell motility assays with bladder carcinoma cells and colorectal carcinoma cells, we report, to the contrary, that loss of p53 can decrease cell motility and invasion. For migration of the single cell studied in isolation, loss of function of the tum...

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Literature Corpus work: 2c833480-89cc-550e-a7d5-a99f6128fa96
DOI: 10.1101/380600

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