Article

Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma

1998-03-01

Abstract excerpt

Abstract Asthma has been increasing in industrialized countries. Evidence suggests that asthma is caused by a Th2 immune response to inhaled environmental Ags and that childhood infections protect against this. We have shown that bacterial DNA contains motifs, centered on unmethylated CpG dinucleotides, which induce Th1-type responses. We hypothesized that the Th1 effect of these CpG motifs may oppose the Th2 type...

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Literature Corpus work: 2c52dc4c-a136-512e-aa4f-2d7e28be1f09
DOI: 10.4049/jimmunol.160.6.2555

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