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Article

Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2021

Seese Sarah E, Deml Brett, Muheisen Sanaa, Sorokina Elena, Semina Elena V

Abstract excerpt

BACKGROUND: The male-abnormal 21 like (MAB21L) genes are important in human ocular development. Homozygous loss of MAB21L1 leads to corneal dystrophy in all affected individuals along with cataracts and buphthalmos in some. The molecular function and downstream pathways of MAB21L factors are largely undefined. RESULTS: We generated the first mab21l1 zebrafish mutant carrying a putative loss-of-function allele,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33570754
DOI: 10.1002/dvdy.312
PMCID: PMC8349561

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