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Article

Immune Responses to AAV in Clinical Trials

2011-06-20

Abstract excerpt

Findings in the first clinical trial in which an adeno-associated virus (AAV) vector was introduced into the liver of human subjects highlighted an issue not previously identified in animal studies. Upon AAV gene transfer to liver, two subjects developed transient elevation of liver enzymes, likely as a consequence of immune rejection of transduced hepatocytes mediated by AAV capsid-specific CD8+ T cells. Studies...

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Identifiers and source

Literature Corpus work
2aa93c27-a8ff-590d-a2d3-8acfc861eb0e
DOI
10.2174/156652311796150354
Open publication

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Immune Responses to AAV in Clinical TrialsDOI 10.2174/156652311796150354
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