Article

Deciphering signaling specificity with interpretable deep neural networks

2018-03-25

Abstract excerpt

Protein kinase phosphorylation is a prevalent post-translational modification (PTM) regulating protein function and transmitting signals throughout the cell. Defective signal transductions, which are associated with protein phosphorylation, have been revealed to link to many human diseases, such as cancer. Defining the organization of the phosphorylation-based signaling network and, in particular, identifying kina...

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Literature Corpus work: 2a2c34c3-109c-5c3b-b8c3-fcf66bc851fa
DOI: 10.1101/288647

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