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Article

UBE2G1 Governs the Destruction of Cereblon Neomorphic Substrates

2018-08-09

Abstract excerpt

The immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide as well as the novel cereblon modulating agents (CMs) including CC-122, CC-220 and cereblon-based proteolysis-targeting chimaeras (PROTACs) repurpose the Cul4-RBX1-DDB1-CRBN (CRL4 CRBN ) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with an E1 ubiquitin-act...

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Literature Corpus work
2a1cb286-6a00-585f-8dae-e23fcbfed7e1
DOI
10.1101/389098
Open publication

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