Article
The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism.
Annals of neurology - 1 Sept 2004
Healy Daniel G, Abou-Sleiman Patrick M, Ahmadi Kourosh R, Muqit Miratul M K, Bhatia Kailash P, Quinn Niall P, Lees Andrew J, Latchmann David S, Goldstein David B, Wood Nicholas W
Abstract excerpt
Mutations in the PINK1 gene (PARK6), a putative serine-threonine kinase, cause autosomal recessive Parkinson's disease. PINK1 functions as a protein kinase and confers protective effects in the mitochondria, where it is primarily located. We assessed in a population of European ancestry whether common genetic variation in this novel gene influences nonmendelian forms of Parkinson's disease. We defined the linkage...
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