Article
Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.
American journal of human genetics - 1 Oct 2002
Coffee Bradford, Zhang Fuping, Ceman Stephanie, Warren Stephen T, Reines Daniel
Abstract excerpt
Fragile X syndrome is caused by an expansion of a polymorphic CGG triplet repeat that results in silencing of FMR1 expression. This expansion triggers methylation of FMR1's CpG island, hypoacetylation of associated histones, and chromatin condensation, all characteristics of a transcriptionally i...
Topics
- Acetylation
- Alleles
- Azacitidine
- DNA Methylation
- Decitabine
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Heterochromatin
- Histones
- Humans
- Lysine
- Nerve Tissue Proteins
- RNA-Binding Proteins
- Transcriptional Activation
- Trinucleotide Repeats
- Tumor Cells, Cultured