Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.

American journal of human genetics - 1 Oct 2002

Coffee Bradford, Zhang Fuping, Ceman Stephanie, Warren Stephen T, Reines Daniel

Abstract excerpt

Fragile X syndrome is caused by an expansion of a polymorphic CGG triplet repeat that results in silencing of FMR1 expression. This expansion triggers methylation of FMR1's CpG island, hypoacetylation of associated histones, and chromatin condensation, all characteristics of a transcriptionally inactive gene. Here, we show that there is a graded spectrum of histone H4 acetylation that is proportional to CGG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA Methylation
Share to Fragile X Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lysine

Share to Nerve Tissue Proteins

Share to RNA-Binding Proteins

Share to Transcriptional Activation

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 12232854
DOI: 10.1086/342931
PMCID: PMC378545

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.PMID 12232854Read ↗

The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome.Semantic proximity Read ↗

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome.Semantic proximity Read ↗

Spatially coordinated heterochromatinization of distal short tandem repeats in fragile X syndromeSemantic proximity Read ↗

Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations.Semantic proximity Read ↗

Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.Semantic proximity Read ↗

Small Molecules Targeting H3K9 Methylation Prevent Silencing of Reactivated FMR1 Alleles in Fragile X Syndrome Patient Derived Cells.Semantic proximity Read ↗

Mosaic H3K9me3 at BREACHes predicts synaptic gene expression associated with fragile X syndrome cognitive severitySemantic proximity Read ↗

FRA2A is a CGG repeat expansion associated with silencing of AFF3.Semantic proximity Read ↗

Targeted Reactivation of <i>FMR1</i> Transcription in Fragile X Syndrome Embryonic Stem CellsSemantic proximity Read ↗

Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.Semantic proximity Read ↗

BRD4 recruitment desilences transcription without erasure or depletion of repressive chromatinSemantic proximity Read ↗

MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the <i>FMR1</i> locus in fragile X syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.