Article

Ovarian cancers with low CIP2A tumor expression constitute an APR-246 sensitive disease subtype

2021-03-31

Abstract excerpt

Identification of ovarian cancer (OvCa) patient subpopulations with increased sensitivity to targeted therapies could offer significant clinical benefit. We report that 22% of the high grade OvCa tumors at diagnosis express CIP2A oncoprotein at low levels. CIP2A low OvCa tumors have significantly lower likelihood of disease relapse after standard chemotherapy, but yet a portion of relapsed tumors retain their CIP...

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Literature Corpus work: 29d28cbd-8e81-5601-b2ba-c5e3718a84f8
DOI: 10.1101/2021.03.31.437804

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