Article

WNK1/HSN2 Regulates Neural Development via GSK3β

2022-02-28

Abstract excerpt

With no lysine kinase 1 (WNK1) phosphorylates and activates STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress responsive kinase 1 (OSR1) to regulate ion homeostasis in the kidney. Mutations in WNK1 result in dysregulation of the WNK1-SPAK/OSR1 pathway and cause pseudohypoaldosteronism type II (PHAII), a form of hypertension. WNK1 is also involved in the autosomal dominant neuropath...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 294b0979-1bea-5f02-8119-aaace41a24f2
DOI: 10.21203/rs.3.rs-1383513/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

WNK1/HSN2 Regulates Neural Development via GSK3βDOI 10.21203/rs.3.rs-1383513/v1Read

WNK signaling is involved in neural development via Lhx8/Awh expression.Semantic proximity Read

WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio).Semantic proximity Read

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.Semantic proximity Read

Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.Semantic proximity Read

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Semantic proximity Read

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.Semantic proximity Read

(WNK)ing at death: With-no-lysine (Wnk) kinases in neuropathies and neuronal survival.Semantic proximity Read

Human hypertension caused by mutations in WNK kinases.Semantic proximity Read

Hereditary sensory and autonomic neuropathies.Semantic proximity Read

Mechanisms of disease in hereditary sensory and autonomic neuropathies.Semantic proximity Read

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.Semantic proximity Read

Expression pattern analysis and characterization of the hereditary sensory and autonomic neuropathy 2 A (HSAN2A) gene with no lysine kinase (WNK1) in human dorsal root ganglionSemantic proximity Read