Article

Human enterochromaffin cells and apical-out intestinal organoids as models for human sapovirus infection

2026-03-08

Abstract excerpt

Human sapovirus is increasingly recognized as a significant cause of acute viral gastroenteritis, but in vitro studies have been limited due to the previous lack of cell models. In this study, we optimized two novel in vitro models for sapovirus infection: the human enteroendocrine cell (EEC) line GOT1 and apical-out 3D human enteroids. Using 31 sapovirus-positive fecal samples, we compared these models with the...

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Literature Corpus work: 28f9cea2-6c8a-5feb-88b6-28ddcd8bae43
DOI: 10.64898/2026.03.06.710023

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