Article

Therapeutic role of 2-stearoxyphenethyl phosphocholine targeting microtubule dynamics and Wnt/β-catenin/EMT signaling in human colorectal cancer cells

2023-05-18

Abstract excerpt

The inhibition of cell death, perturbation of microtubule dynamics, and acceleration of Wnt/β-catenin/epithelial-mesenchymal transition (EMT) signaling are fundamental processes in the progression and metastasis of colorectal cancer (CRC). To explore the role of 2-stearoxyphenethyl phosphocholine (stPEPC), an alkylphospholipid-based compound, in CRC, we conducted an MTT assay, cell cycle analysis, western blot ana...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2857daa9-aaaa-5806-80c2-af21fc3318bd
DOI: 10.21203/rs.3.rs-2910821/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Therapeutic role of 2-stearoxyphenethyl phosphocholine targeting microtubule dynamics and Wnt/β-catenin/EMT signaling in human colorectal cancer cellsDOI 10.21203/rs.3.rs-2910821/v1Read

Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stressSemantic proximity Read

E-Cadherin/β-Catenin Complex: A Target for Anticancer and Antimetastasis Plants/Plant-derived CompoundsSemantic proximity Read

Prognostic Biomarkers of Cell Proliferation in Colorectal Cancer (CRC): From Immunohistochemistry to Molecular Biology TechniquesSemantic proximity Read

Small Molecule Destabilizer of β-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors.Semantic proximity Read

A Destabilizer of Both Wnt/β-Catenin and Ras/ERK Pathways Suppresses Cancer Stem Cell Activation in Colorectal CancerSemantic proximity Read

CDCA3 mediates p21-dependent proliferation by regulating E2F1 expression in colorectal cancerSemantic proximity Read

Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colonSemantic proximity Read

Targeting WEE1 by adavosertib inhibits the malignant phenotypes of hepatocellular carcinoma.Semantic proximity Read

Alisol A attenuates malignant phenotypes of colorectal cancer cells by inactivating PI3K/Akt signalingSemantic proximity Read

STEAP3 promotes colon cancer cell proliferation and migration via regulating histone acetylationSemantic proximity Read

Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosisSemantic proximity Read

Chalcone Derivative CX258 Suppresses Colorectal Cancer via Inhibiting the TOP2A/Wnt/β-Catenin SignalingSemantic proximity Read