Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A three-dimensional model of the human transglutaminase 1: insights into the understanding of lamellar ichthyosis.

Journal of molecular modeling - 1 Jan 2007

Boeshans Karen M, Mueser Timothy C, Ahvazi Bijan

Abstract excerpt

The stratum corneum, the outer layer of the epidermis, serves as a protective barrier to isolate the skin from the external environment. Keratinocyte transglutaminase 1 (TGase 1) catalyzes amide crosslinking between glutamine and lysine residues on precursor proteins forming the impermeable layers of the epidermal cell envelopes (CE), the highly insoluble membranous structures of the stratum corneum. Patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Calcium
Share to Catalysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ichthyosis, Lamellar

Share to Keratinocytes

Share to Protein Structure, Secondary

Share to Sequence Homology, Amino Acid

Share to Transglutaminases

Source

Identifiers

PMID: 17024410
DOI: 10.1007/s00894-006-0144-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A three-dimensional model of the human transglutaminase 1: insights into the understanding of lamellar ichthyosis.PMID 17024410Read ↗

Molecular profiling of lamellar ichthyosis pathogenic missense mutations on the structural and stability aspects of TGM1 protein.Semantic proximity Read ↗

Transglutaminase 1 mutations in lamellar ichthyosis. Loss of activity due to failure of activation by proteolytic processing.Semantic proximity Read ↗

Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1.Semantic proximity Read ↗

Long-Term Faithful Recapitulation of Transglutaminase 1–Deficient Lamellar Ichthyosis in a Skin-Humanized Mouse Model, and Insights from Proteomic StudiesSemantic proximity Read ↗

A novel mutation in the transglutaminase-1 gene in an autosomal recessive congenital ichthyosis patient.Semantic proximity Read ↗

Cholesterol 3-sulfate interferes with cornified envelope assembly by diverting transglutaminase 1 activity from the formation of cross-links and esters to the hydrolysis of glutamine.Semantic proximity Read ↗

A novel homozygous mutation 371delA in TGM1 leads to a classic lamellar ichthyosis phenotype.Semantic proximity Read ↗

Mutations of transglutaminase-1 in Chinese patients with autosomal recessive congenital ichthyosis: a case report with clinical and genetic analysis of Chinese cases reported in literature.Semantic proximity Read ↗

New mutations in the transglutaminase 1 gene in three families with lamellar ichthyosis.Semantic proximity Read ↗

Novel transglutaminase-1 mutations and genotype-phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis in the USA.Semantic proximity Read ↗

Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopesSemantic proximity Read ↗

Ichthyosis: A Road Model for Skin Research.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.