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Cooperation, Defection, and Collapse: A Multiscale Game Theory Framework for Emphysema Progression

2026-07-15

Abstract excerpt

In the current paper, pulmonary emphysema is hypothesized to emerge from a nonlinear breakdown of cooperation across two tightly coupled systems: the extracellular matrix (ECM) crosslink network and the cellular populations responsible for its maintenance. To formalize this concept, we construct a game-theoretic model that unifies the mechanical failure, inflammatory changes, and percolation-driven tissue collapse...

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Literature Corpus work
2848a10d-a68f-5e4a-b0f1-9422bf973070
DOI
10.20944/preprints202607.1143.v1
Open publication

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Cooperation, Defection, and Collapse: A Multiscale Game Theory Framework for Emphysema ProgressionDOI 10.20944/preprints202607.1143.v1
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