Article

Landscape of human miRNA variation and conservation using Annotative Database of miRNA Elements, ADmiRE

2017-08-16

Abstract excerpt

MicroRNAs (miRNAs) are the most abundant class of non-coding RNAs that regulate expression of >60% genes and are frequently deregulated in many human diseases. Sequence variants in miRNAs are expected to have a high impact on miRNA function. However, the lack of miRNA variant annotation and prioritization guidelines has hampered this analysis from whole genome/exome sequencing (WGS/WES) studies. Through the develo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 282d5d1c-4c56-5600-90bb-0bb2da1939c8
DOI: 10.1101/177170

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Landscape of human miRNA variation and conservation using Annotative Database of miRNA Elements, ADmiREDOI 10.1101/177170Read

Classification of miRNA-related sequence variations.Semantic proximity Read

miRmedon: confident detection of microRNA editingSemantic proximity Read

MiRLog and dbmiR: Prioritization and functional annotation tools to study human microRNA sequence variants.Semantic proximity Read

Detection of A-to-I microRNA editing with miRmedon reveals widespread co-editing of mature microRNA in the human brainSemantic proximity Read

miRge 2.0: An updated tool to comprehensively analyze microRNA sequencing dataSemantic proximity Read

MSDD: a manually curated database of experimentally supported associations among miRNAs, SNPs and human diseases.Semantic proximity Read

Copy number variations burden on miRNA genes reveals layers of complexities involved in the regulation of pathways and phenotypic expression.Semantic proximity Read

Human genetic variation and its effect on miRNA biogenesis, activity and function.Semantic proximity Read

MicroRNAs and genomic variations: from Proteus tricks to Prometheus gift.Semantic proximity Read

OPTIMIR, a novel algorithm for integrating available genome-wide genotype data into miRNA sequence alignment analysisSemantic proximity Read

Tumor IsomiR Encyclopedia (TIE): a pan-cancer database of miRNA isoformsSemantic proximity Read

Functional genetic variation of human miRNAs and phenotypic consequences.Semantic proximity Read