Article

Effects of parental age and polymer composition on short tandem repeat <i>de novo</i> mutation rates

2023-12-23

Abstract excerpt

Short tandem repeats (STRs) are hotspots of genomic variability in the human germline because of their high mutation rates, which have long been attributed largely to polymerase slippage during DNA replication. This model suggests that STR mutation rates should scale linearly with a father’s age, as progenitor cells continually divide after puberty. In contrast, it suggests that STR mutation rates should not scale...

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Identifiers and source

Literature Corpus work: 2815c778-89c5-52e7-a653-29b5f518129b
DOI: 10.1101/2023.12.22.573131

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