Article

<i>ParaDISM</i> : Precise mapping of short reads to genes with highly homologous regions

2026-05-21

Abstract excerpt

<h4>Background</h4> Genes with highly similar genomic copies (paralogs, tandem duplications and pseudogenes) pose a major challenge for Short-Read High Throughput Sequencing (srHTS). High sequence similarity makes it difficult to unambiguously identify the sequences of origin of short reads. This results in misalignment artifacts which can propagate through bioinformatic pipelines and increase error rates in vari...

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Literature Corpus work: 27dd4b3e-87ad-5fbf-9c63-385ed8c437af
DOI: 10.64898/2026.05.19.726275

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