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Article

USP7-mediated ERβ stabilization mitigates ROS accumulation and promotes osimertinib resistance by suppressing PRDX3 SUMOylation in non-small cell lung carcinoma.

Cancer letters - 1 Feb 2024

Meng Yunchong, Lin Wei, Wang Na, Wei Xiao, Mei Peiyuan, Wang Xiaojun, Zhang Chi, Huang Quanfu, Liao Yongde

Abstract excerpt

Osimertinib resistance is regarded as a major obstacle limiting survival beneﬁts for patients undergoing treatment of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). However, the underlying mechanisms of acquired resistance remain unclear. In this study, we report that estrogen receptor β (ERβ) is highly expressed in osimertinib-resistant NSCLC and plays a pivotal role in...

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PMID: 38097136
DOI: 10.1016/j.canlet.2023.216587

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