Article

Design and synthesis of inhibitors of the non-canonical NF-ĸB pathway for the treatment of prostate and pancreatic cancer

2016-01-01

Abstract excerpt

The dysregulation of the transcription factor NF-κB has been linked with multiple pathologies including cancers, inflammatory diseases and autoimmune conditions. Under basal conditions, NF-κB is held in an inactive state in the cytosol. Upon stimulation, in response to cellular stress, NF-κB translocates to the nucleus where it is able to activate gene expression. These genes include a number of pro-inflammatory c...

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Literature Corpus work: 27065dcc-2116-5b3c-ae3a-823dc7d2c937
DOI: 10.48730/dcqx-x219

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