Article

Co-activation of LIN28A and CTNNB1 disturbs cortical neuronal migration and pia mater integrity

2024-08-02

Abstract excerpt

Developmental signalling pathways act in stage and tissue dependent relation and mis-activation can drive tumour formation. The RNA-binding protein LIN28A maintains stemness and is overexpressed in embryonal brain tumours. Activating mutations of CTNNB1 - the WNT pathway effector - have been reported in respective brain tumours. The aim of this study was to investigate the interplay of these oncogenic proteins du...

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Literature Corpus work: 26f6e5b9-5a3d-56b3-8711-2dee1bd00759
DOI: 10.1101/2024.08.01.606182

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