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Cell-type-specific Mendelian randomization analysis of brain single-nucleus eQTLs and neuromyelitis optica spectrum disorder risk.

Multiple sclerosis and related disorders - 1 Sept 2026

Ye Hong, Huang Songmin, Shi Leiyun, Chai Lixiang

Abstract excerpt

BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is a rare central nervous system autoimmune disease characterized by aquaporin-4 antibody-mediated astrocyte injury. Although genetic risk variants in the major histocompatibility complex (MHC) region have been consistently implicated in NMOSD susceptibility, the cellular context in which these genetic risk factors operate in the brain remains...

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PMID: 42401156
DOI: 10.1016/j.msard.2026.107340

Genes

AQP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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