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Resistance to EGFR inhibitors in lung cancer occurs through horizontal transfer and is associated with increased caveolins expression

2022-02-20

Abstract excerpt

Resistance to treatment is a major clinical problem and a major cause of cancer-related deaths. Understanding the biological basis of resistance acquisition is of utmost importance to improve the clinical management of cancer patients. NGS analysis of human lung cancer (LC) tumors from patients that relapsed after treatment with EGFR-tyrosine kinase inhibitors (TKI), revealed that the p.T790M resistance mutation i...

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Literature Corpus work
263206b1-794d-5b43-a90f-5cdfc7d9db99
DOI
10.1101/2022.02.20.481179
Open publication

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Resistance to EGFR inhibitors in lung cancer occurs through horizontal transfer and is associated with increased caveolins expressionDOI 10.1101/2022.02.20.481179
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