Article

Differentiating Hyperkinetic and Hypokinetic Motor Features in the Progression of Huntington’s Disease

2025-04-21

Abstract excerpt

<h4>Background</h4> Huntington’s disease (HD) is a monogenic neurodegenerative disorder typically characterized by chorea, a hyperkinetic motor feature. Historical data suggest that hypokinetic features, like rigidity and bradykinesia, become more prominent in later stages of HD. No evidence-based analysis has confirmed this observation. Additionally, several motor features of the disease are not clearly defined a...

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Literature Corpus work: 25d60698-b1dd-5b7e-a62c-808a2054b3a8
DOI: 10.1101/2025.04.17.25325819

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