Article

Genetic modifiers of psychiatric, motor, and cognitive symptoms in Huntington’s disease

2026-06-22

Abstract excerpt

The Enroll-HD natural history platform provides rich longitudinal phenotypes enabling genome-wide analyses across diverse clinical domains. Psychiatric symptoms are a major source of morbidity in Huntington’s disease (HD), yet the genetic architecture underlying their onset is poorly understood. We analyzed ∼18,000 people with HD (PwHD) to define genetic determinants of ages at psychiatric, motor, and cognitive sy...

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Literature Corpus work: f46dc88d-65ed-5c41-a715-1607d8480a8a
DOI: 10.64898/2026.06.16.26355789

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