Article

Cell detoxification of secondary metabolites by P4-ATPase mediated vesicle transport

2022-05-03

Abstract excerpt

Mechanisms for cellular detoxification of drug compounds are of significant interest in human health. Cyclosporine A (CsA) and tacrolimus (FK506) are widely known antifungal and immunosuppressive microbial natural products. However, both compounds can result in significant side effects when used as immunosuppressants. The insect pathogenic fungus Beauveria bassiana shows resistance to CsA and FK506. However, the...

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Literature Corpus work: 25b42808-f200-5c9b-8444-a34d0c0cf135
DOI: 10.1101/2022.05.03.490477

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