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A novel zebrafish-based <i>in vivo</i> model of Zika virus infection unveils NS4A as a key viral determinant of neuropathogenesis

2024-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Infection of pregnant women by Zika virus (ZIKV) is associated with severe neurodevelopmental defects in newborns through poorly defined mechanisms. Here, we engineered a zebrafish in vivo model of ZIKV infection to circumvent limitations of existing mammalian models. Leveraging the unique tractability of this system, we gained unprecedented access to the ZIKV-infected brain at early developmen...

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Literature Corpus work
251d85c2-824f-557a-bda7-61ed1a0da015
DOI
10.1101/2024.01.20.576493
Open publication

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A novel zebrafish-based <i>in vivo</i> model of Zika virus infection unveils NS4A as a key viral determinant of neuropathogenesisDOI 10.1101/2024.01.20.576493
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