Article
Dermaseptins as potential antirabies compounds.
Vaccine - 2 Aug 2019
Mechlia Mohamed Ben, Belaid Afifa, Castel Guillaume, Jallet Corinne, Mansfield Karen L, Fooks Anthony R, Hani Khaled, Tordo Noël
Abstract excerpt
Over the last 20 years, natural peptides playing a key role in defense mechanisms and innate immunity have been isolated from unicellular organisms. Amphibian skin secretes dermaseptins, 24-34 amino acids in length that have a wide antimicrobial spectrum incorporating yeast, fungi, protozoa, bacteria and enveloped viruses. The anti-rabies virus (RABV) activity of dermaseptins S3 (30aa) and S4 (28aa) from...
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