Article

microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs

2020-01-30

Abstract excerpt

<h4>ABSTRACT</h4> MiR-140 is selectively expressed in cartilage. Deletion of the entire miR-140 locus in mice results in growth retardation and early-onset osteoarthritis-like pathology, however the relative contribution of miR-140-5p or miR-140-3p to the phenotype remains to be determined. An unbiased small RNA sequencing approach identified miR-140-3p as significantly more abundant (>10-fold) than miR-140-5p in...

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Literature Corpus work: 24e13807-21d8-540c-989a-16de0a0cca08
DOI: 10.1101/2020.01.29.925206

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