Article

Impact on risk stratification of overlap syndrome phenotype (Brugada and Long QT type 3) in patients with E1784K mutation in SCN5A

2025-08-08

Abstract excerpt

<h4>Introduction</h4> Risk stratification of patients with the SCN5A-E1784K mutation is challenging because they can express Brugada syndrome, long QT syndrome (LQTS), or both phenotypes (overlap syndrome). This study compared arrhythmic risk in patients with overlap syndrome versus single phenotype presentations. <h4>Methods</h4> We retrospectively enrolled patients aged 12 and older carrying the SCN5A-E1784K m...

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Literature Corpus work: 2406a73e-9225-5ac4-b886-4d18569ae8ba
DOI: 10.1101/2025.08.05.25333081

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