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The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection.

International journal of environmental research and public health - 2 Jan 2021

Qi Jing, Zhou Yang, Hua Jiao, Zhang Liying, Bian Jialin, Liu Beibei, Zhao Zicen, Jin Shuilin

Abstract excerpt

COVID-19 patients always develop multiple organ dysfunction syndromes other than lungs, suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the viral susceptibility of other organs is important for a deeper understanding of viral pathogenesis. Angiotensin-converting enzyme II (ACE2) is the receptor protein of SARS-CoV-2, and TMPRSS2 promotes virus proliferation and transmission....

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PMID: 33401657
DOI: 10.3390/ijerph18010284
PMCID: PMC7794913

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