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Article

Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents

27 Sept 2018

Abstract excerpt

Bmi-1 is overexpressed in colorectal cancer (CRC) and served as a novel therapeutic target for the treatment of CRC. A series of novel cyanoenone-modified diterpenoid analogs was synthesized and investigated for their antiproliferative activity against CRC cells. The results showed that most of these compounds exhibited potent antiproliferative and Bmi-1 inhibitory activity. Among them, the most active compound...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30429953
DOI: 10.1021/acsmedchemlett.8b00345

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