Article

MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control

2022-09-30

Abstract excerpt

There remains an urgent need for new therapies for drug-resistant epilepsy (DRE). Sodium channel blockers are effective for seizure control in common forms of epilepsy, but loss of sodium channel function underlies some genetic forms of epilepsy. Approaches that provide bi-directional control of sodium channel expression are needed. MicroRNAs (miRNA) are small non-coding RNAs which negatively regulate gene express...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 238353fe-f3e1-5e89-bc5f-2cbc6e3bd31b
DOI: 10.1101/2022.09.29.510105

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure controlDOI 10.1101/2022.09.29.510105Read

Differential Expression Analysis of miRNAs and mRNAs in Epilepsy Uncovers Potential BiomarkersSemantic proximity Read

MicroRNAs in epilepsy: pathophysiology and clinical utilitySemantic proximity Read

EpimiRBase: a comprehensive database of microRNA-epilepsy associationsSemantic proximity Read

A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene.Semantic proximity Read

miRNA-Coordinated Schizophrenia Risk Network Cross-Talk With Cardiovascular Repair and Opposed GliomagenesisSemantic proximity Read

Altered gene expression profile in a mouse model of SCN8A encephalopathy.Semantic proximity Read

Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy.Semantic proximity Read

Na <sub>V</sub> 1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and <i> Scn8a <sup>N1768D/+</sup> </i> gain-of-function miceSemantic proximity Read

Antisense oligonucleotide therapy for SCN2A gain-of-function epilepsySemantic proximity Read

MicroRNAs in mental health: from biological underpinnings to potential therapies.Semantic proximity Read

miR-146a and miR-200b alter cognition by targeting NMDA receptor subunitsSemantic proximity Read

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.Semantic proximity Read