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Association between Angiotensin Converting Enzyme Gene I/D and Promoter Polymorphisms and Diabetic Nephropathy in Type2 Diabetic Patients in Ismailia, Egypt

2023-08-28

Abstract excerpt

BACKGROUND: There is mounting evidence that the chronic activation of renal and systemic ACE, which results in the production of Angiotensin II, is a critical step in the pathogenesis of DN. Chronic ACE activation causes an increase in intraglomerular pressure, tissue damage, pro-inflammatory effects, and promotes fibrosis. AIM: The purpose of this study was to determine if ACE polymorphisms (I/D rs4646994 and pr...

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Literature Corpus work
233f0877-6986-5a9c-abcf-f11e1c86c367
DOI
10.21203/rs.3.rs-3257050/v1
Open publication

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