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Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulence

2024-03-05

Abstract excerpt

<h4>Summary</h4> The identification of novel molecular targets for antifungal drugs is critical due to limited treatment options and drug-resistance threats. We screened inhibitors of small GTPases, molecular switches in signal transduction, in Trichophyton rubrum , the primary cause of dermatophytosis. Our study found that chemical and genetic inhibition of Cdc42 and Rac GTPases, which are involved in cellular...

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Literature Corpus work
2313e8a2-306f-52a3-8976-1bdb2c9e9e6b
DOI
10.1101/2024.03.04.583433
Open publication

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Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulenceDOI 10.1101/2024.03.04.583433
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