Article

Monkeypox Virus Clade IIb Isolate Exhibits Reduced Virulence Relative to Clade IIa Isolates in Multiple Murine Models

2025-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Monkeypox virus (MPXV) is the causative agent of mpox disease in humans. The virus is comprised of two clades, Central African clade I and West African clade II with case fatality rates of ∼11 and ∼4%, respectively. Since the discovery of mpox disease in 1970, the virus has been restricted to Africa. However, in 2022, a previously unrecognized subclade IIb caused the largest global outbreak of m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22f4cb54-9e6d-5664-9003-f649e563ded8
DOI: 10.64898/2025.12.10.693532

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Monkeypox Virus Clade IIb Isolate Exhibits Reduced Virulence Relative to Clade IIa Isolates in Multiple Murine ModelsDOI 10.64898/2025.12.10.693532Read

Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal modelSemantic proximity Read

Enhanced mouse virulence of mpox virus clade Ib over clade IIb despite genomic changes caused by human-to-human transmissionSemantic proximity Read

Attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestorSemantic proximity Read

Emergence of Clade Ib Monkeypox Virus—Current State of EvidenceSemantic proximity Read

Virulence Differences of Monkeypox Virus Clades 1, 2a and 2b.1 in a Small Animal ModelSemantic proximity Read

Strong and early monkeypox virus-specific immunity associated with mild disease after intradermal clade-IIb-infection in CAST/EiJ-miceSemantic proximity Read

Exploring the genomic basis of Mpox virus-host transmission and pathogenesisSemantic proximity Read

A comprehensive review of monkeypox virus and mpox characteristicsSemantic proximity Read

Modeling the pathogenic infection of mpox virus clade IIb in type I and II interferon pathway double deficient miceSemantic proximity Read

Genomic analyses of recently emerging clades of mpox virus reveal gene deletion and single nucleotide polymorphisms that correlate with altered virulence and transmissionSemantic proximity Read

Mpox virus clade evolution and epidemiology in Africa: a systematic review of genetic variability and clinical impactSemantic proximity Read

Mpox, Caused by the MPXV of the Clade IIb Lineage, Goes GlobalSemantic proximity Read