Article

Enhanced mouse virulence of mpox virus clade Ib over clade IIb despite genomic changes caused by human-to-human transmission

2025-09-22

Abstract excerpt

The recently emerged clade Ib of mpox virus (MPXV) is spreading rapidly across Central and West Africa raising concerns about its potential virulence. Similar to clade IIb lineage B.1, which was responsible for the 2022 global outbreak, clade Ib exhibits sustained human-to-human transmission and a pattern of APOBEC3-associated genomic mutations. Here, we show that clade Ib displays enhanced cell-to-cell disseminat...

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Literature Corpus work: 0c5d1d07-d13d-512a-adcc-075c7339c00a
DOI: 10.1101/2025.09.22.677787

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