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A membrane-depolarizing toxin substrate of the <i>Staphylococcus aureus</i> Type VII secretion system mediates intra-species competition

2018-10-16

Abstract excerpt

The type VII protein secretion system (T7SS) is conserved across Staphylococcus aureus strains and plays important roles in virulence and interbacterial competition. To date only one T7SS substrate protein, encoded in a subset of S. aureus genomes, has been functionally characterized. Here, using an unbiased proteomic approach, we identify TspA as a further T7SS substrate. TspA is encoded distantly from the T7SS...

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Literature Corpus work
225f294b-edf3-5d8a-90ed-6c04875b4ecd
DOI
10.1101/443630
Open publication

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