Article

Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis

2018-05-14

Abstract excerpt

Gelatinase B/matrix metalloproteinase-9 (MMP-9) triggers multiple sclerosis (MS) and the animal model of experimental autoimmune encephalomyelitis (EAE) by the breakdown of the blood-brain barrier. Interestingly, MMP-9 is beneficial in systemic autoimmunity caused by Fas-deficiency. Fas-deficient ( fas lpr ) and Fas-ligand-deficient mice are protected against EAE. We here investigated the interaction between Fa...

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Literature Corpus work: 2241135b-4eba-58aa-a6fa-8e1cedfc6c0f
DOI: 10.1101/321661

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