Article

Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T- lymphocytopaenia

2024-07-12

Abstract excerpt

<title>Abstract</title> <p>Newborn screening for severe combined immunodeficiency promotes early diagnosis and timely treatment, improving clinical outcomes. Selective T-lymphocytopaenia is found both in haematopoietic cell-intrinsic and thymic stromal cell-intrinsic defects, including congenital athymia which is associated with a T-B + NK + immunophenotype. Without a molecular diagnosis, it is challenging to det...

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Literature Corpus work: 22105166-08ab-5db0-8081-9ab83b8cd932
DOI: 10.21203/rs.3.rs-4668549/v1

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