Article

Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting regulatory T cells

2025-10-30

Abstract excerpt

<h4>SUMMARY</h4> Neutrophils are required for production of protective antibodies in response to the pneumococcal conjugate vaccine (PCV), however, the mechanisms behind that are not known. Here, in exploring mechanisms, we found that depletion of neutrophils at the time of vaccination in female mice led to increased regulatory T cells (Tregs) in the spleen that was accompanied by a dysregulated cytokine environm...

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Literature Corpus work: 21ee1e5c-1bfa-5512-8150-b3eb826dc7ab
DOI: 10.1101/2025.10.28.685204

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