Article

PCPpred: Prediction of Chemically Modified Peptide Permeability Across Multiple Assays for Oral Delivery

2026-01-22

Abstract excerpt

Chemically modified peptides, including cyclic peptides, have emerged as promising candidates for oral delivery yet they face the challenge of low membrane permeability. In this study, the datasets were sourced from CycPeptMPDB, a database for membrane permeability of peptides obtained from different assays. Our quantitative analysis showed a clear discordance between permeability measured using PAMPA and cell-bas...

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Literature Corpus work: 21af8154-211d-5206-8288-3f61c60e132e
DOI: 10.64898/2026.01.19.700485

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