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Recent advances in the development of β-lactamase inhibitors

27 Jul 2020

Abstract excerpt

β-Lactam antibiotics are the most commonly prescribed antibiotics worldwide; however, antimicrobial resistance (AMR) is a global challenge. The β-lactam resistance in Gram-negative bacteria is due to the production of β-lactamases, including extended-spectrum β-lactamases, metallo-β-lactamases, and carbapenem-hydrolyzing class D β-lactamases. To restore the efficacy of BLAs, the most successful strategy is to use...

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PMID: 32720096
DOI: 10.1007/s12275-020-0285-z

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