Article

Increased utrophin expression in healthy and DMD patient derived myoblasts in response to ERK1/2 and EZH2 inhibitor treatment

2026-04-15

Abstract excerpt

<h4>Background</h4> The X-linked muscle wasting disorder Duchenne muscular dystrophy (DMD) is a progressive and ultimately fatal disease caused by loss of function mutations in the dystrophin ( DMD ) gene. Upregulation of utrophin ( UTRN ), an embryonic homologue of dystrophin, has been proposed as a therapeutic option that could ameliorate disease. We previously generated a bioluminescent screen for utrophin-u...

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Literature Corpus work: 217aeba7-d1f2-51d5-a4fb-5456bedb05fe
DOI: 10.64898/2026.04.13.718206

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