Article

Duchenne Muscular Dystrophy Cell Culture Models Created By CRISPR/Cas 9 Gene Editing And Their Application To Drug Screening

2020-02-25

Abstract excerpt

Gene edition methods are an attractive putative therapeutic option for Duchenne muscular dystrophy and they have an immediate application in the generation of research models. To generate two new edited myoblast cultures that could be useful in vitro drug screening, we have optimised a CRISPR/Cas9 gene edition protocol. We have successfully used it in wild type immortalised myoblasts to delete exon 52 of the dyst...

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Literature Corpus work: 59f21f8d-00ab-5a98-9766-a1979ca43175
DOI: 10.1101/2020.02.24.962316

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