Back to search

Article

Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors

2019-03-18

Abstract excerpt

Muscle resident fibro-adipogenic progenitors (FAPs), support muscle regeneration by releasing cytokines that stimulate the differentiation of myogenic stem cells. However, in non-physiological contexts (myopathies, atrophy, aging) FAPs cause fibrotic and fat infiltrations that impair muscle function. We set out to perform a fluorescence microscopy-based screening to identify compounds that perturb the differentiat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
214e938e-946b-562f-b544-b6f29f4c1d04
DOI
10.1101/581363
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitorsDOI 10.1101/581363
Recent Advances in Pre-clinical Development of Adiponectin Receptor Agonist Therapies for Duchenne Muscular DystrophySemantic proximity
Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle <i>in vitro</i>Semantic proximity
Emerging drugs for Duchenne muscular dystrophySemantic proximity
Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and diseaseSemantic proximity
Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro.Semantic proximity
VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.Semantic proximity
Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophySemantic proximity
Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophySemantic proximity
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesisSemantic proximity
A Systematic Review and User Reference of Phenotypic and Molecular Characteristics of Dexamethasone-Mediated C2C12 Muscle Atrophy.Semantic proximity
Large‐scale isolation of human skeletal muscle satellite cells from post‐mortem tissue and development of quantitative assays to evaluate modulators of myogenesisSemantic proximity
Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular DystrophySemantic proximity
Select a neighboring publication to make it the new centre.