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<i>Chryseobacterium indologenes</i> mediates resistance to osimertinib by activating the IGF1R pathway in EGFR-mutant lung adenocarcinoma

2025-10-09

Abstract excerpt

<h4>Introduction</h4> Lung cancers harboring sensitizing epidermal growth factor receptor (EGFR) mutations typically exhibit an initial response to osimertinib; however, the development of resistance is inevitable, and there are currently no approved targeted therapies available once resistance emerges. Accumulating evidence indicates that intra-tumoral bacteria can influence tumor biology and contribute to thera...

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Literature Corpus work
20e97470-52da-585a-bf63-7286c47f27e9
DOI
10.1101/2025.10.08.681060
Open publication

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